Beckman Coulter Multisizer 4e – Particle Size Analyzer and Counter
The Multisizer 4e particle size analyzer and counter is the most precise and versatile particle characterization system on the market, featuring an unmatched measurement range of 0.2 to 1600 μm. The new 10 μm aperture enables the analysis of subcellular particles and microparticles down to 200 nm, while an advanced noise-reduction system for small apertures enhances measurement accuracy.
Acquired data is processed using patented digital pulse processing technology; it can be stored and re-analyzed at a later time. This technology delivers extremely high resolution and accuracy—levels unattainable with other methods—allowing for the detection of a single particle in 1 mL of sample under optimal instrument configuration. Analysis results are independent of particle shape, structure, or optical properties.
The instrument employs the Coulter Principle for particle detection via Electrical Zone Sensing, independent of the nature or optical properties of the particles. This makes it an ideal instrument for detecting and counting a wide variety of particles, such as:
Mammalian cells
Bacteria
Yeast
Abrasives
Toner particles
Cell aggregates
Spheroids
Large protein aggregates
Features
Versatility
Aperture sizes ranging from 10 µm to 2000 µm in diameter to meet current and future requirements
Various aperture options and data-overlay capabilities for analyzing complex samples with broad particle size distributions
Sample detection
Analysis of materials in aqueous or non-aqueous solvents
Ideal for biological or non-biological samples
Particle detection independent of material type or optical properties
Rapid particle counting
Typical count rates of up to 10,000 events per second
Detection and counting of particles with diameters from 0.2 µm to 1600 µm
Sample volumes starting at 5 ml
Data management
Digital pulse data can be stored and re-analyzed as needed
Software compliance with 21 CFR Part 11 for audit control and security
Wide range of calibration beads and V-Check validation controls
Product specifications
Sample volume 0.004 µm³ to 2.145 x 10⁹ fL or µm³
Particle size 0.2 µm – 1600 µm diameter
Volume Continuously selectable from 50 µl to 2,000 µl
Dimensions (WxDxH) 64 x 61 x 51 cm (25.2 x 24 x 20.1 inches)
Volume range 4 to 400 ml
Type Counting instrument
Applications Detection and counting of a wide range of particles
Sample type Aqueous or non-aqueous solvents; biological or non-biological samples
Specifications/Features
Liquid compatibility – All aqueous and non-aqueous electrolyte solutions designed for use with aperture technology are suitable for the Multisizer 4e. Electrolytes should be compatible with glass, fluoropolymers, fluoroelastomers, and stainless steel. Performance data – Aperture current accuracy: ± 0.4% of the set value; polarity error: < 0.5%
Sample modules – Binning from 3 to 400 channels (number and range can be adjusted subsequently if required) | Pulse data is digitized and can be processed to provide up to 400 size channels for a selected pulse range. Number of channels and range are adjustable subsequently if required. Apertures from 10 µm to 2000 µm (nominal diameter)
Condition: Used, very good
