Multi-Stage Liquid Impinger (MSLI)
The MSLI was the first cascade impactor/impinger specifically designed for inhaler testing.
Whilst the 4-Stage MSLI does not offer the number of stages of the ACI or NGI, it does, by definition, have no inter-stage losses and is suitable throughout the range 30-100 L/min.
Unlike the ACI and NGI, the collection stages of the MSLI are kept moist, which eliminates the problem of particle bounce associated with conventional impactors.
Advantages include:
• 4 Stages between 1.7 and 13 microns
• Operates between 30 and 100 L/min
• Virtually no inter-stage losses
• Eliminates particle bounce and hence re-entrainment problems
• Easy and quick drug recovery
Decription:
The MSLI is a versatile four–stage liquid impinger which can be used for determining the APSD of DPIs in the case of USP Chapter <601> and of MDIs and DPIs in the case of Ph.Eur. Chapter 2.9.18.
The MSLI is fitted with PTFE seals as standard.
The design is such that at a flow rate of 60 L/min, the cut-off diameters of Stages 1, 2, 3 and 4 are 13, 6.8, 3.1 and 1.7 microns respectively. Stage 5 comprises an integral paper filter to capture the remaining fraction of particles less than 1.7 microns.
The MSLI has, by definition, no interstage losses and is suitable for use throughout the range 30 - 100 L/min.
Unlike the ACI and NGI, the collection stages of the MSLI are kept moist which helps to reduce the problem of re-entrainment sometimes experienced when using more conventional impactors. It employs the same induction port as the other cascade impactors.
During the mensuration, the sintered glass impingement stages are positioned using calibrated gauge blocks to ensure that the correct jet-to-plate distance is maintained.
Condition: Used, like new
